尊龙凯时·(中国区)人生就是搏!

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Jun 28,2023
CAR-T疗法主要针对白血病与恶性淋巴瘤，此研究中构建沉默PD-1的shRNA载体质粒，测序后质粒的鉴定通过尊龙凯时 - 人生就是搏!进行
Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR is constructed. The plasmids sequenced were fully identified by Medicilon.
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CAR-T疗法主要针对白血病与恶性淋巴瘤，此研究中构建沉默PD-1的shRNA载体质粒，测序后质粒的鉴定通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
索拉非尼的无定形固体分散体用于开发改良型口服生物利用度高的速释片剂，PK研究通过尊龙凯时 - 人生就是搏!进行
The SOR ASD tablets exhibited approximately 50% higher relative bioavailability in dogs than the marketed SOR tablet product, Nexavar®. The pharmacokinetic (PK) study of SOR ASD tablets and Nexavar® tablets was performed by Medicilon.
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索拉非尼的无定形固体分散体用于开发改良型口服生物利用度高的速释片剂，PK研究通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
TAK-931是一种高度特异性的CDC7抑制剂，具有抗肿瘤功效，体内药效研究通过尊龙凯时 - 人生就是搏!进行
In vivo efficacy studies in J558 allograft models in combination with anti-mPD-1, anti-mPD-L1, and anti-mCTLA-4 antibodies were performed at Medicilon.
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TAK-931是一种高度特异性的CDC7抑制剂，具有抗肿瘤功效，体内药效研究通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
GS-5801是一种有效的KDM5抑制剂，具有抗HBV活性，GS-5801通过尊龙凯时 - 人生就是搏!合成
GS-5801, a potent inhibitor of KDM5, has antiviral activity against HBV in a primary human hepatocytes infection model, with the cellular permeability, oral bioavailability. GS-5801 was synthesized by Medicilon.
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GS-5801是一种有效的KDM5抑制剂，具有抗HBV活性，GS-5801通过尊龙凯时 - 人生就是搏!合成
Jun 28,2023
QF-036是一种高效的HIV-1抑制剂，具有良好的和药代动力学特性，PK研究通过尊龙凯时 - 人生就是搏!进行
The favourable viral inhibitory activity and pharmacokinetic properties provide critical support for QF-036 as a promising anti-HIV therapeutic candidate. The pharmacokinetic studies were performed by Medicilon.
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QF-036是一种高效的HIV-1抑制剂，具有良好的和药代动力学特性，PK研究通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
设计合成一种新型选择性的口服有效苏氨酸酪氨酸激酶 (TTK) 抑制剂，PK研究均通过尊龙凯时 - 人生就是搏!进行
TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carried out by Medicilon.
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设计合成一种新型选择性的口服有效苏氨酸酪氨酸激酶 (TTK) 抑制剂，PK研究均通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
TR-107是人类线粒体蛋白酶ClpP的有效激活剂，PK分析通过尊龙凯时 - 人生就是搏!进行
The pharmacokinetic properties of TR‐107 were compared with other known ClpP activators including ONC201 and ONC212. TR‐107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evaluated for pharmacokinetic properties in ICR mice by Medicilon.
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TR-107是人类线粒体蛋白酶ClpP的有效激活剂，PK分析通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
SKLB-197是一种有效且高度选择性的ATR抑制剂，PK研究通过尊龙凯时 - 人生就是搏!进行
SKLB-197, exhibits good pharmacokinetic properties, could be a promising lead compound for drug discovery targeting ATR. The pharmacokinetic (PK) studies were performed by Medicilon.
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SKLB-197是一种有效且高度选择性的ATR抑制剂，PK研究通过尊龙凯时 - 人生就是搏!进行
Jun 28,2023
H11-HLE是一种工具分子，可用于研究Fc在介导免疫检查点治疗中的作用，具有抗肿瘤功效
Immune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent anti-tumor efficacy in mouse syngeneic tumor models.
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H11-HLE是一种工具分子，可用于研究Fc在介导免疫检查点治疗中的作用，具有抗肿瘤功效
Jun 28,2023
JND003是一种新型选择性ERRα激动剂，可缓解非酒精性脂肪肝和胰岛素抵抗，PK和组织分布测定通过尊龙凯时 - 人生就是搏!进行
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver diseases. Estrogen-related receptor alpha (ERRα) is a viable target for NAFLD.
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JND003是一种新型选择性ERRα激动剂，可缓解非酒精性脂肪肝和胰岛素抵抗，PK和组织分布测定通过尊龙凯时 - 人生就是搏!进行
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